Piezoelectric biosensors

Authors:  Petr Skládal

Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic

Journal: Trends in Analytical Chemistry

Abstract: Progress in the field of piezoelectric (quartz crystal microbalance-based) biosensors in the recent five years is reviewed. In addition to the traditional immunosensing assays, the combination with detection of nucleic acids is addressed, biosensing of microbes and novel applications in the field of cellular biology are highlighted. The signal enhancing strategies based on both biochemical cascades (often involving nanoparticles) and technological improvements of instrumentation are discussed.

Keywords: Quartz crystal microbalance, Immunosensor, Nucleic acid sensor, Eukaryotic cellular studies, Instrumentation for piezosensors