LOVE-SAW sensors consists of a thicker quartz piezoelectric substrate with an interdigitated transducer (IDT) on one end of the surface of the substrate, acting as signal input, and a second one, on the other end of the surface substrate, acting as the output. An alternating current applied to the input transducer generates a mechanical wave which propagates along the sensor device, from the input port to the output port. The wave travels confined in a guiding layer of a few microns height at the top part of the surface. When the properties of a film attached to the surface change (due to changes of mass, conformation, analyte binding, etc…), the propagation properties of the acoustic wave travelling along the sensor change as-well. The precise detection of the changes in those properties enables the characterization of mass and structural changes in the vicinity of the sensor surface with high sensitivity and resolution.