Noticias para apartado News

Bio-Logic, new distributor of our electrochemistry instruments

February 22th 2016

AWSensors is proud to announce the agreement with the French multinational Bio-Logic Science Instruments. We are now the original equipment manufacturer (OEM) for the Acoustic Sensing System distributed by this company, a real-time and sensitive system to monitor surface-bound interactions, such as adsorption and desorption processes, characterization of molecular interactions, protein conformational changes, etc.

As a result of this agreement, Bio-logic has exclusive rights to sell AWSensors platforms for electrochemistry applications because our platforms can be coupled to a Bio-Logic potentiostat/galvanostat system to perform e-QCM measurements for the most demanding experimental requirements.

AWSensors will keep selling directly its instruments for bio applications.

Bio-Logic company has a wide expertise in scientific instruments for high-performance applications such as:

  •  Electrochemistry
  • Spectroscopy and photosynthesis
  • Batteries and Power Test
  • Test material
  • Scanning electrochemical systems
  • Electrophysiology

Bio-Logic is headquartered in France, in the town of Claix, and it has offices in the US and India and a large and growing network of distributors worldwide. Therefore, this agreement allows AWSensors to offer local distributors and local technical support to customers.

We appreciate the confidence that Bio-logic has on AWSensors technology and we are convinced that this agreement will be extremely beneficial for everyone interested in cutting-edge acoustic sensing technology.

Unión Europea - FEDER

 

DNA

H2020 Project LiqBiopSens: A new liquid biopsy platform for early detection of colorrectal cancer

December 10th 2015

We are proud to announce that the European Comission awarded a grant of a total value of 2’7M euros to our project LIQBIOPSENS for early detection of colorectal cancer by carrying out liquid biopsy. The grant was awarded within Horizon2020 and specifically in the call entitled “ICT-28-2015: Cross cutting ICT Key Enabling Technologies”.

 

AWSensors will coordinate this H2020 project during the next 3 years (2016-2018). The overall aim of this project is the further development and validation in real settings of a novel diagnostic platform for the early and fast detection of circulating tumor DNA (ctDNA) and their KRAS and BRAF mutations associated to colorectal cancer through blood samples.

Liquid Biopsy platform LiqBiopSens features

The main features of LiqBiopSens are:

  1. Reliability (detection rates vary from 95-100 %)
  2. Low-Cost
  3. Sensitivity (in the zM range)
  4. Multiplexing capabilities (analysis of 27 KRAS and BRAF mutations simultaneously)
  5. Short analysis time (30-60 min.)
  6. User-friendly interface
  7. Flexibility

LIQBIOPSENS platform is based on the integration of two novel complementary technologies:

  • DGL© technology property of DestiNA Genomics Ltd, capable of delivering faster, more error-free detection of DNA and their mutations than current enzyme-based detection systems, making ‘false positive’ results a thing of the past.
  • A novel high resolution acoustic wave microsensor technology property of AWSensors, that allows an accurate, inexpensive, label-free, direct and real-time transduction method to quantitatively evaluate the results of the application of the mentioned DGL© technique.

However, solution proposed by the LIQBIOPSENS project relies on the multidisciplinary integration of different key enabled technologies. Accordingly, LiqBiopSens will be accomplished by AWSensors and Destina Genomics in collaboration with the following partners:

Liquid Biopsy platform LiqBiopSens concept

The operating concept of our project is described in the following representative scheme:

Early detection of colorrectal cancer by liquid biopsy

ctDNA amplicons produced in chamber (1) are denatured and transferred to the sensors surface via   microfluidics (2) where hybridization with DGL probes takes place; mutation‐discrimination is carried out during the injection (3) of novel probes which click selectively on the target DNA (4) while acoustic detection exploits functionalized nanoparticles (5).

Colorectal cancer, the second most common cause of cancer death

The most frequently occurring forms of cancer in the EU are colorectal, breast, prostate and lung cancers. In men, lung cancer is the most frequent cause of cancer death, while in women, it is breast cancer. In both men and women, colorectal cancer is the second most common cause of cancer death.

The “gold standard” for identifying the type and extent of a cancer is a tissue biopsy, in which a small sample of tissue is taken from the suspected tumour and histologically examined. While this procedure can provide important information about the patient disease, tissue biopsy can be painful, represents a single snap-shot in time, is subjected to significant selection bias and if the tumour tested was first detected by palpation or imaging, it may already be so large that the disease is well advanced. Furthermore, when the tumour tissue is removed or it is inaccessible, these genotyping techniques are impossible. Therefore, cancer remains a ghost disease when primary tumours are removed through surgery, meaning that there are not tools to assess the efficiency of treatments or prevent metastasis.

Liquid Biopsy, a revolution in the fight against cancer

It has long been known that solid tumors release DNA in the blood and the load of circulating tumor DNA (ctDNA) has been correlated to staging and prognosis. However, only recent advances in the sensitivity and accuracy of DNA analysis have allowed for genotyping of somatic changes found in tumors by interrogating ctDNA. This technique is known as ‘Liquid Biopsy’ and it is based on the analysis of a biomarker that can be easily isolated from many body fluids (blood, saliva, urine, ascites, pleural effusion, etc.).

 

Successful implementations of liquid biopsy techniques to track tumor dynamics in real time and for the early detection, such as LIQBIOPSENS, are going to revolutionise how clinicians fight against cancer.

AWS probe module for immersion

A new sensor module for immersion

Northwestern University, typically ranked among the top 15 of all U.S. universities in US, has become our customer. We are delighted to begin our expansion into the U.S. market with our relationship with Northwestern.

Our specific collaboration is with Prof. Kenneth Shull, from the Department of Materials Science and Engineering. He is one of the most prestigious researchers on the properties of polymer surfaces and interfaces, with a research emphasis on the adhesion of “soft materials”, including traditional pressure-sensitive adhesives and highly specialized polymeric gels commonly used in biomedical applications.

 Because of this collaboration, we have just launched a new sensor module specially designed for immersion.

AWS sensor module for immersion

Currently, researchers are using hand-made devices but they usually cause several inconvenients:

 

  • Lack of chemical resistance.
  • Weakness.
  • High volume of sample is wasted
  • Sealing is not hermetical.

The new AWS EQCM probe module solves all these issues and offers other advantages

Cover of AWS probe sensor module

  • You can immerse the sensor module even in very strong or hot solutions (up to 150 degrees) because the parts in contact with the liquid are made of PEEK and PTFE.
  • You can visualize the sensor during the experiment because the chamber is made of see-through material.
  • You do not have to worry about sealing. A PTFE cover seals the glass vial and includes holes for the reference and counter electrodes and holes for PTFE tubbing for controlling atmosphere or bubling inside the chamber.
  • You can easily replace and clean all the parts of the probe module.

 

The AWS EQCM Probe module is designed to operate with standard wrapped QCM sensors of 14 mm or 1” diameter with contacts, as well as AWS-HFF sensors.

 

Do you feel this new sensor module could be useful for your research?

 

Visit our Custom Solutions and tell us your needs

We would be pleased to help you

Bioeconomy in Spain

Bioeconomy in the Spanish Public Budget for 2016

Aug 25th 2015

Spanish Parliament starts to debate today the public budget for the next year. So that, we would like to review what are the plans to invest in research and innovation. According to the budget for the Secretary of Innovation, bioeconomy will be one of the priorities for the Spanish Government in 2016.

 

Bioeconomy figure; food, biomass, public health, energy security, sustainable production, economic and social development

What is bioeconomy?

The bioeconomy definition according to the EFIB (European Forum for the Bioeconomy) is the following:

Bioeconomy encompasses the production of renewable biological resources and their conversion into food, feed, bio-based products and bioenergy via innovative and efficient technologies.

AWSensors tech has important applications in bioeconomy such as environmental monitoring, secure food and water, bioenergy or biomaterials. EU is promoting and funding projects in these fields in order to make the transition to a more resource efficient society and the Spanish Government is following this policy too.

Spain will boost the Bioeconomy Strategy in the public budget to research and development for 2016

Spanish government plans to invest 1,765 million euros in direct aid for innovation projects and 2,446 million euros for loans to enterprises. The resources allocated to direct aid will increase up to 15 per cent over this year and loans will decrease to 9 per cent. The government will give priority to areas considered most in need of development in science and technology such as Andalucia, Extremadura, Canarias, Castilla-La Mancha, Murcia, Galicia and Asturias. Among the actions to be undertaken in these regions, Bioeconomy will be boosted in the agri-food, biomass, bioenergy and bioproducts fields.

Furthermore, the Centre for the Development of Industrial Technology (CDTI), the main driver of innovation in Spain, will have 30 million euros more for direct aid, 35.7% more than the previous year. The Spanish High Council Scientific Research (CSIC) will have 467 million euros next year and the Institute of Health Carlos III (ISCIII), 165 millions.

In spite of this state budget for 2016, Spain is still the 17th european country in gross domestic expenditure on R&D according to Eurostat.

5 reasons to use HFF-AWS biosensing platform to ensure food safety in honey production

June 22th 2015

The control of chemical residues is essential in honey’s marketing to ensure consumer safety. Equipments available in the market reach the required limit of detection (LOD) (e.g Liquid Cromatography -HPLC) but are not suitable for in-situ implantation in honey packaging industry because they are more expensive and time-consuming and require highly qualified staff. Other approaches available in the market, although faster and without the need of qualified staff, do not reach the required LODs.

However, piezoelectric immunosensors like HFF-AWS based on High Fundamental Frequency Quartz Crystal Microbalance, combined with an antigen-antibody recognition process, are a good alternative or complementary technology for chemical residues control in food. Why? Let us tell you only 5 strong reasons to justify it:

  • Lower cost
    You will only need a very affordable equipment such as AWS platform
  • Suitable for in-situ implantation in hone packaging industry
    The equipment is easily adapted to an industrial process
  • Less sample/reagent consumption
    You will need less than 3 ul sample
  • Label-free and real time transduction
    Direct detection.
  • LOD improved

Analytical parameters (µg L-1)HFF-QCM immunosensorELISA1SPR immunosensor2
I500.620.741.06
LOD0.080.150.03
LOQ0.160.220.11
WR0.16 – 2.370.22 – 2.470.11 – 10.07

AWSensors showed its work entitled “HFF-QCM immunosensor for fast and sensitive detection of DDT in Honey” in the Third International Congress on Quality and Food Safe Acofesal 2015 held in Valencia. We are pleased to share it with you. You can look it up HERE.

AWSensors exhibits how HFF-AWS biosensor reaches ELISA limit of detection for carbaryl pesticide in the 4th International Conference on Biosensing Technology in Lisbon

AWSensors showed its work on carbaryl pesticide during the 4th International Conference on Biosensing Technology held in Lisbon, Portugal, last month. Attendees were very interested in how AWS platform provides ELISA limit of detection. Therefore, we would like to explain and share on line the work entitled “Further sensitivity enhancement of HFF-QCM immunosensors for pesticides”.

Foto LisboaAWSensors have successfully developed a High Fundamental Frequency Quartz Crystal Microbalance that improves sensitivity of QCM biosensors. Taking advantage of this technology, AWS developed and tested a renewed highly sensitive HFF piezoelectric immunosensor for its use in pesticide detection, using insecticide carbaryl as a model analyte. To this purpose, 100 MHz quartz crystals were used as the transducer elements of the biosensor and a monoclonal antibody-based
competitive immunoassay was integrated as the sensing specific bio-recognition event. The biosensing interface was improved by employing mixed self-assembled monolayers of alkane thiols as intermediate layers for surface functionalization. This approach allowed the covalent attachment of the assay conjugate on the gold electrode surface in a more orderly and stable way than with simple SAMs. Moreover, a very low concentration of LIB-CNH45 monoclonal antibody was used for the competitive immunoassays. The sensitivity enhancement achieved turns the HFF-AWS pesticide immunosensor into one of the most sensitive analytical tools for this kind of low molecular compounds. Don’t lose the opportunity to take advantage of this innovation. AWSensors offers its new technology at the best price.

CLICK TO DOWNLOAD the poster about this work